Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6140750 | 0.84 | SIRT2 (0.59) | SIRT2MAPTHDAC3HDAC1HDAC2 | |
| SCHEMBL338745 | 0.81 | SIRT2 (0.56) | SIRT2HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL27540427 | 0.81 | MAPT (0.68) | MAPTHDAC3HDAC1HDAC2SMN1; SMN2 | |
| SCHEMBL1366907 | 0.81 | PTPN1 (0.60) | SIRT2MAPTHDAC3HDAC1HDAC2 | |
| SCHEMBL339194 | 0.80 | MEN1 (0.71) | SIRT2MAPTHDAC3HDAC1HDAC2 | |
| SCHEMBL9696775 | 0.80 | CACNA1B (0.67) | MAPTHDAC3HDAC1HDAC2SMN1; SMN2 | |
| SCHEMBL7752677 | 0.79 | F10 (0.79) | MAPTHDAC3HDAC1HDAC2SMN1; SMN2 | |
| SCHEMBL14281039 | 0.79 | TOP1 (0.58) | SIRT2MAPTHDAC3HDAC1HDAC2 | |
| SCHEMBL15770775 | 0.76 | MEN1 (0.53) | SIRT2MAPTHDAC3HDAC1HDAC2 | |
| SCHEMBL28100858 | 0.76 | MAPK13 (0.65) | SIRT2MAPTHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137462-A2 | METHODS FOR TREATING COGNITIVE DISORDERS USING INHIBITORS OF HISTONE DEACETYLASE | ENVIVO PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |
| WO-2008055068-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2008-05-08 | — | — | WO | disclosed |