Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PPME1 | Q9Y570 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953111 | 1.00 | PKM (0.40) | PKML3MBTL1PPME1MEN1KMT2A | |
| SCHEMBL3249803 | 0.65 | PKM (0.57) | PKML3MBTL1PPME1MEN1KMT2A | |
| SCHEMBL3249807 | 0.65 | PKM (0.57) | PKML3MBTL1PPME1MEN1KMT2A | |
| SCHEMBL3249809 | 0.65 | PKM (0.57) | PKML3MBTL1PPME1MEN1KMT2A | |
| SCHEMBL7966701 | 0.64 | IGF1R (0.56) | PKML3MBTL1PPME1MEN1KMT2A | |
| SCHEMBL7966703 | 0.64 | IGF1R (0.56) | PKML3MBTL1PPME1MEN1KMT2A | |
| SCHEMBL7966704 | 0.64 | IGF1R (0.56) | PKML3MBTL1PPME1MEN1KMT2A | |
| SCHEMBL7964790 | 0.64 | PKM (0.58) | PKML3MBTL1PPME1MEN1KMT2A | |
| SCHEMBL7964783 | 0.64 | PKM (0.58) | PKML3MBTL1PPME1MEN1KMT2A | |
| SCHEMBL7964786 | 0.64 | PKM (0.58) | PKML3MBTL1PPME1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225346-B1 | FOR THERAPY AND PROPHYLAXIS OF CELL PROLIFERATIVE DISORDERS OR CELL DIFFERENTIATION DISORDERS ASSOCIATED WITH PARTICULAR TYROSINE KINASES BY INHIBITING ONE OR MORE ABNORMAL TYROSINE KINASE ACTIVITIES | SUGEN, INC. | 2001-05-01 | — | — | US | disclosed |