SCHEMBL7953560

SCHEMBL7953560

O=C(O)CCCCCc1oc2cc(O)ccc2c(=O)c1-c1ccc(O)cc1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.75
ALDH2 P05091 8/20 0.49
MAOA P21397 7/20 0.49
MAOB P27338 7/20 0.49
ESR1 P03372 4/20 0.49
KDM4E B2RXH2 3/20 0.48
ALDH1A1 P00352 3/20 0.48
ACP1 P24666 2/20 0.47
ESR2 Q92731 2/20 0.47
HPGD P15428 2/20 0.46
CASP1 P29466 2/20 0.46
CASP7 P55210 2/20 0.46
HSD17B10 Q99714 2/20 0.46
MEN1 O00255 1/20 0.46
TP53 P04637 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2D6 P10635 1/20 0.46
MAPT P10636 1/20 0.46
CYP2C9 P11712 1/20 0.46
MAPK1 P28482 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2182484 0.83 PPARG (0.91) PPARGESR1KDM4EALDH1A1ACP1
SCHEMBL3421118 0.83 PPARG (0.62) PPARGMAOAMAOBESR1KDM4E
SCHEMBL14094348 0.82 PPARG (0.74) PPARGESR1KDM4EALDH1A1ACP1
SCHEMBL2181592 0.80 PPARG (0.81) PPARGESR1KDM4EALDH1A1ACP1
SCHEMBL3488072 0.79 MEN1 (0.51) PPARGMAOAMAOBESR1KDM4E
SCHEMBL14094350 0.77 PPARG (0.69) PPARGESR1KDM4EALDH1A1ACP1
SCHEMBL13970374 0.75 PPARG (0.71) PPARGESR1KDM4EALDH1A1ESR2
SCHEMBL14094346 0.75 PPARG (0.61) PPARGMAOAMAOBESR1KDM4E
SCHEMBL14185184 0.74 PPARG (0.71) PPARGESR1KDM4EALDH1A1ACP1
SCHEMBL8484064 0.73 PPARG (0.60) PPARGALDH2MAOAMAOBESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6255497-B1 DAIDZIN DERIVATIVES AS ENZYME INHIBITORS OF ALDEHYDE DEHYDROGENASE; USEFUL IN TREATING ALCOHOLISM THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. 2001-07-03 US disclosed