SCHEMBL8484064

SCHEMBL8484064

O=c1c(-c2ccc(O)cc2)c(CS(=O)(=O)Cl)oc2cc(O)ccc12

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.60
ESR1 P03372 5/20 0.53
ESR2 Q92731 3/20 0.51
KDM4E B2RXH2 5/20 0.50
ALDH1A1 P00352 5/20 0.50
CYP3A4 P08684 4/20 0.50
HPGD P15428 4/20 0.50
HSD17B10 Q99714 4/20 0.50
MAPK1 P28482 3/20 0.50
TP53 P04637 3/20 0.50
MAPT P10636 3/20 0.50
CYP2C9 P11712 3/20 0.50
CYP2D6 P10635 2/20 0.50
CYP2C19 P33261 2/20 0.50
MEN1 O00255 2/20 0.50
CASP1 P29466 2/20 0.50
CASP7 P55210 2/20 0.50
KMT2A Q03164 2/20 0.50
CYP19A1 P11511 4/20 0.49
ACP1 P24666 4/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3421118 0.79 PPARG (0.62) PPARGESR1ESR2KDM4EALDH1A1
SCHEMBL2181592 0.79 PPARG (0.81) PPARGESR1ESR2KDM4EALDH1A1
SCHEMBL365536 0.79 ESR1 (0.65) PPARGESR1ESR2KDM4EALDH1A1
SCHEMBL2182484 0.77 PPARG (0.91) PPARGESR1ESR2KDM4EALDH1A1
SCHEMBL14185183 0.77 PPARG (0.63) PPARGESR1ESR2KDM4EALDH1A1
SCHEMBL17159756 0.76 PPARG (0.62) PPARGESR1ESR2KDM4EALDH1A1
SCHEMBL5488938 0.76 PPARG (0.59) PPARGESR1ESR2KDM4EALDH1A1
SCHEMBL14185242 0.75 PPARG (0.65) PPARGESR1ESR2KDM4EALDH1A1
SCHEMBL14185184 0.75 PPARG (0.71) PPARGESR1ESR2KDM4EALDH1A1
SCHEMBL14185194 0.74 PPARG (0.57) PPARGESR1ESR2KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5981775-A FROM A 2'-HYDROXYDEOXYBENZOIN USING PREPARED N,N'-DIMETHYL(CHLOROMETHYLENE)AMMONIUM CHLORIDE AS A REACTANT IN BORONTRIFLUORIDE ETHERATE OR OTHER LEWIS ACID AS A SOLVENT BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) 1999-11-09 US disclosed