Sugi Predict

Sugi Predict / Compounds / SCHEMBL7953740

SCHEMBL7953740

SCHEMBL7953740

NC(=O)Cc1c(C2CC2)n(Cc2ccccc2)c2ccc(OCCCP(=O)(O)O)cc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ PLA2G2A P14555 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7963218 0.91 PLA2G2A (0.83) PLA2G2A
SCHEMBL7963214 0.91 PLA2G2A (0.83) PLA2G2A
SCHEMBL13484799 0.85 PLA2G2A (1.00) PLA2G2A
SCHEMBL5001034 0.85 PLA2G2A (1.00) PLA2G2A
SCHEMBL7965980 0.84 PLA2G2A (1.00) PLA2G2A
SCHEMBL29362159 0.84 PLA2G2A (1.00) PLA2G2A
SCHEMBL8926090 0.84 PLA2G2A (0.72) PLA2G2A
SCHEMBL7963397 0.83 PLA2G2A (1.00) PLA2G2A
SCHEMBL7962828 0.79 PLA2G2A (1.00) PLA2G2A
SCHEMBL8926087 0.78 PLA2G2A (0.71) PLA2G2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0620215-B1 1H-indole-3-acetamide derivatives as sPLA2 inhibitors LILLY CO ELI (US) 1999-08-18 — — EP claimed
EP-0620215-A1 1H-indole-3-acetamide derivatives as sPLA2 inhibitors ELI LILLY AND COMPANY (US) 1994-10-19 — — EP claimed
US-6252084-B1 THERAPY FOR SEPSIS SHOCK ELI LILLY AND COMPANY 2001-06-26 — — US disclosed
EP-0620215-B1 1H-indole-3-acetamide derivatives as sPLA2 inhibitors LILLY CO ELI (US) 1999-08-18 — — EP disclosed
EP-0620215-A1 1H-indole-3-acetamide derivatives as sPLA2 inhibitors ELI LILLY AND COMPANY (US) 1994-10-19 — — EP disclosed