Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.40 |
| ▸ | RBP4 | P02753 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16801678 | 0.78 | SLC6A4 (0.56) | MAPTLMNASLC6A4POLBHTR1D | |
| SCHEMBL28097371 | 0.77 | MAPT (0.54) | MAPTLMNASLC6A4POLBHTR1D | |
| SCHEMBL7220992 | 0.75 | MAPT (0.51) | MAPTLMNASLC6A4POLBHTR1D | |
| SCHEMBL6383779 | 0.75 | CNR1 (0.57) | MAPTLMNASLC6A4POLBHTR1D | |
| SCHEMBL615817 | 0.73 | AVPR1A (0.55) | MAPTLMNASLC6A4AVPR1ANR4A2 | |
| SCHEMBL615958 | 0.72 | AVPR1A (0.61) | MAPTLMNAAVPR1A | |
| SCHEMBL4670751 | 0.70 | SLC6A4 (0.81) | LMNASLC6A4POLBHTR1A | |
| SCHEMBL614661 | 0.70 | AVPR1A (0.52) | MAPTLMNAAVPR1ANR4A2 | |
| SCHEMBL16801734 | 0.70 | SLC6A4 (0.69) | MAPTLMNASLC6A4HTR1A | |
| SCHEMBL7219966 | 0.70 | MAPT (0.51) | MAPTLMNASLC6A4POLBHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262087-B1 | HAVE HIGH AFFINITY FOR D4 RECEPTORS; USEFUL IN THE TREATMENT OF CERTAIN PSYCHIATRIC AND NEUROLOGIC DISORDERS, INCLUDING PSYCHOSIS, DEPRESSION AND ANXIETY. | H. LUNDBECK A/S (DK) | 2001-07-17 | — | — | US | disclosed |