Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28784977 | 0.78 | HTR1B (0.50) | HTR1BALDH1A1KDM4ETDP1KCNA3 | |
| SCHEMBL4289478 | 0.77 | HTR1B (0.59) | HTR1BALDH1A1KDM4ETDP1KCNA3 | |
| SCHEMBL29577853 | 0.77 | HTR1B (0.54) | HTR1BALDH1A1KDM4ETDP1KCNA3 | |
| SCHEMBL442767 | 0.77 | HTR1B (0.54) | HTR1BALDH1A1KDM4ETDP1KCNA3 | |
| SCHEMBL7457103 | 0.75 | HTR1B (0.52) | HTR1BALDH1A1KDM4ETDP1KCNA3 | |
| Methane SCHEMBL10959030 | 0.75 | HTR1B (0.52) | HTR1BALDH1A1KDM4ETDP1KCNA3 | |
| Lithium SCHEMBL6571336 | 0.75 | HTR1B (0.52) | HTR1BALDH1A1KDM4ETDP1KCNA3 | |
| SCHEMBL9874308 | 0.74 | MAPT (0.47) | ALDH1A1KDM4ETDP1HSD17B10GAA | |
| SCHEMBL997311 | 0.73 | HTR1B (0.55) | HTR1BALDH1A1KDM4ETDP1KCNA3 | |
| SCHEMBL5701147 | 0.73 | HTR1B (0.50) | HTR1BALDH1A1KDM4ETDP1KCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6031103-A | Process for manufacturing 1-[3-cyclopentyl -2(R)-[1(R)-hydroxycarbamoyl)-2-(3, 4, 4-trimethyl -2, 5-D ioxo-1-imidazolidinyl) ethyl] propionyl] piperidine | HOFFMANN-LA ROCHE INC. (US) | 2000-02-29 | — | — | US | claimed |
| US-6172238-B1 | Process for manufacturing 1-[3-cyclopentyl-2(R)-[1(R)-hydroxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]propionyl]piperidine | HOFFMANN-LA ROCHE INC. | 2001-01-09 | — | — | US | disclosed |
| JP-2000063358-A | CHIRAL SUCCINIC ACID DERIVATIVE | F HOFFMANN LA ROCHE AG | 2000-02-29 | — | — | JP | disclosed |
| US-6031103-A | Process for manufacturing 1-[3-cyclopentyl -2(R)-[1(R)-hydroxycarbamoyl)-2-(3, 4, 4-trimethyl -2, 5-D ioxo-1-imidazolidinyl) ethyl] propionyl] piperidine | HOFFMANN-LA ROCHE INC. (US) | 2000-02-29 | — | — | US | disclosed |