Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.64 |
| ▸ | MMP9 | P14780 | 10/20 | 0.64 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.64 |
| ▸ | MMP1 | P03956 | 4/20 | 0.64 |
| ▸ | MMP14 | P50281 | 3/20 | 0.64 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.61 |
| ▸ | MMP13 | P45452 | 3/20 | 0.51 |
| ▸ | BMP1 | P13497 | 4/20 | 0.50 |
| ▸ | MMP3 | P08254 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5034658 | 0.91 | MMP2 (0.68) | MMP2MMP9ADAM17MMP1MMP14 | |
| SCHEMBL7945731 | 0.90 | MMP2 (0.57) | MMP2MMP9ADAM17MMP1MMP14 | |
| SCHEMBL7954596 | 0.90 | MMP2 (0.63) | MMP2MMP9ADAM17MMP1MMP14 | |
| SCHEMBL7945656 | 0.85 | MMP2 (0.77) | MMP2MMP9ADAM17MMP1MMP14 | |
| SCHEMBL1378426 | 0.85 | MMP2 (0.50) | MMP2MMP9ADAM17MMP1MMP14 | |
| SCHEMBL7956126 | 0.84 | MMP2 (0.55) | MMP2MMP9ADAM17MMP1MMP14 | |
| SCHEMBL7959404 | 0.84 | MMP2 (0.56) | MMP2MMP9ADAM17MMP1MMP14 | |
| SCHEMBL7959937 | 0.81 | MMP2 (0.69) | MMP2MMP9ADAM17MMP1MMP14 | |
| SCHEMBL5033356 | 0.81 | MMP2 (0.69) | MMP2MMP9ADAM17MMP1MMP14 | |
| SCHEMBL7409638 | 0.81 | MMP2 (0.77) | MMP2MMP9ADAM17MMP1MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |