Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 19/20 | 0.73 |
| ▸ | ADRA1D | P25100 | 15/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 15/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 7/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 7/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7236022 | 0.96 | ADRA1A (0.71) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7241726 | 0.95 | ADRA1A (0.73) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7237695 | 0.94 | ADRA1A (0.64) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7245402 | 0.93 | ADRA1A (0.63) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7952573 | 0.92 | ADRA1A (0.74) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7236378 | 0.92 | ADRA1A (0.63) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7251173 | 0.90 | ADRA1A (0.61) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7236493 | 0.90 | ADRA1A (0.59) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7242493 | 0.89 | ADRA1A (0.60) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7959795 | 0.88 | ADRA1A (0.57) | ADRA1AADRA1DADRA1BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310076-B1 | TREATING BENIGN PROSTATIC HYPERPLASIA, LOWERING INTRAOCULAR PRESSURE, INHIBITING CHOLESTEROL SYNTHESIS, TREATING DISEASES MEDIATED BY ALPHA-1 RECEPTORS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-10-30 | — | — | US | disclosed |
| US-6211198-B1 | BENIGN PROSTATE HYPERPLASIA; INTRAOCULAR PRESSURE; HYPOTENSIVE AGENTS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-04-03 | — | — | US | disclosed |