Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.54 |
| ▸ | LPL | P06858 | 7/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 7/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | F11 | P03951 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30240794 | 0.84 | DGAT1 (0.54) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL24932981 | 0.84 | DGAT1 (0.54) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL3259842 | 0.84 | DGAT1 (0.54) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL30240864 | 0.84 | DGAT1 (0.54) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL2021079 | 0.83 | DGAT1 (0.53) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL2185526 | 0.82 | DGAT1 (0.52) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL17129299 | 0.82 | DGAT1 (0.52) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL17129006 | 0.80 | DGAT1 (0.53) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL17129297 | 0.80 | DGAT1 (0.55) | DGAT1LPLLIPGCA1CA2 | |
| SCHEMBL19000571 | 0.80 | DGAT1 (0.57) | DGAT1LPLLIPGCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010190-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010191-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |