Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 17/20 | 0.68 |
| ▸ | MMP9 | P14780 | 17/20 | 0.68 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.61 |
| ▸ | MMP1 | P03956 | 2/20 | 0.61 |
| ▸ | MMP14 | P50281 | 2/20 | 0.61 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.61 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7959937 | 0.94 | MMP2 (0.69) | MMP2MMP9ADAMTS5MMP1MMP14 | |
| SCHEMBL5033356 | 0.94 | MMP2 (0.69) | MMP2MMP9ADAMTS5MMP1MMP14 | |
| Hydroxyamine SCHEMBL7688383 | 0.92 | MMP2 (0.67) | MMP2MMP9ADAMTS5MMP1MMP14 | |
| SCHEMBL7945656 | 0.89 | MMP2 (0.77) | MMP2MMP9ADAMTS5MMP1MMP14 | |
| SCHEMBL7952666 | 0.89 | MMP2 (0.67) | MMP2MMP9ADAMTS5MMP1MMP8 | |
| SCHEMBL7952667 | 0.89 | MMP2 (0.67) | MMP2MMP9ADAMTS5MMP1MMP8 | |
| SCHEMBL7945731 | 0.85 | MMP2 (0.57) | MMP2MMP9ADAMTS5MMP1MMP14 | |
| SCHEMBL6719641 | 0.83 | MMP2 (0.62) | MMP2MMP9MMP1MMP14ADAM17 | |
| SCHEMBL5034658 | 0.83 | MMP2 (0.68) | MMP2MMP9ADAMTS5MMP1MMP14 | |
| SCHEMBL6722448 | 0.83 | MMP2 (0.64) | MMP2MMP9MMP1MMP14ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |