Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 15/20 | 0.51 |
| ▸ | MMP9 | P14780 | 14/20 | 0.51 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 3/20 | 0.46 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 2/20 | 0.44 |
| ▸ | MMP14 | P50281 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7954589 | 1.00 | MMP2 (0.51) | MMP2MMP9ADAMTS5MMP8MMP13 | |
| SCHEMBL1379461 | 0.97 | MMP2 (0.52) | MMP2MMP9ADAMTS5MMP8MMP13 | |
| SCHEMBL1376076 | 0.93 | MMP2 (0.53) | MMP2MMP9ADAMTS5MMP8MMP13 | |
| SCHEMBL1380534 | 0.88 | MMP2 (0.54) | MMP2MMP9ADAMTS5MMP8MMP13 | |
| SCHEMBL1380533 | 0.88 | MMP2 (0.54) | MMP2MMP9ADAMTS5MMP8MMP13 | |
| SCHEMBL1380810 | 0.88 | MMP2 (0.50) | MMP2MMP9ADAMTS5MMP8MMP13 | |
| SCHEMBL1380809 | 0.88 | MMP2 (0.50) | MMP2MMP9ADAMTS5MMP8MMP13 | |
| SCHEMBL5034648 | 0.83 | MMP2 (0.52) | MMP2MMP9ADAMTS5MMP13MMP1 | |
| SCHEMBL1379922 | 0.80 | MMP2 (0.46) | MMP2MMP9ADAMTS5MMP13MMP1 | |
| SCHEMBL1379920 | 0.80 | MMP2 (0.46) | MMP2MMP9ADAMTS5MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |