Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12310929 | 0.84 | SMN1; SMN2 (0.63) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL14931534 | 0.84 | SMN1; SMN2 (0.66) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL13588549 | 0.83 | SMN1; SMN2 (0.61) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL6444645 | 0.81 | SMN1; SMN2 (0.66) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL1106991 | 0.80 | SMN1; SMN2 (0.69) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL21370385 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL7361107 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL7373429 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL7325083 | 0.78 | SMN1; SMN2 (0.59) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL8546297 | 0.78 | SMN1; SMN2 (0.59) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172064-B1 | METALLOPROTEASE INHIBITOR; ANTIARTHRITIC AGENTS, ANTIDIABETIC AGENTS; ANTITUMOR AGENTS | GLAXO WELLCOME INC. | 2001-01-09 | — | — | US | disclosed |