Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141122 | 0.85 | SMN1; SMN2 (0.58) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL16150930 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL16150929 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL27819904 | 0.84 | SMN1; SMN2 (0.71) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL14931534 | 0.83 | SMN1; SMN2 (0.66) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL10438528 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL12310929 | 0.81 | SMN1; SMN2 (0.63) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL1106991 | 0.80 | SMN1; SMN2 (0.69) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL7954680 | 0.79 | SMN1; SMN2 (0.58) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL3625014 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2CYP1A2CYP2D6MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0578745-A1 | PHOSPHORUS CONTAINING COMPOUNDS AS INHIBITORS OF RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-01-19 | — | — | EP | disclosed |
| WO-1992017490-A1 | PHOSPHORUS CONTAINING COMPOUNDS AS INHIBITORS OF RETROVIRUSES | THE UPJOHN COMPANY (US) | 1992-10-15 | — | — | WO | disclosed |