Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 14/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 14/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807923 | 0.82 | SLC6A2 (0.43) | SLC6A2SLC6A3SLC6A4CYP2D6KCNH2 | |
| SCHEMBL5592232 | 0.82 | SLC6A4 (0.41) | SLC6A2SLC6A3SLC6A4CYP2D6KCNH2 | |
| SCHEMBL6993490 | 0.79 | SLC6A3 (0.52) | SLC6A2SLC6A3SLC6A4CYP2D6KCNH2 | |
| SCHEMBL6993234 | 0.75 | SLC6A4 (0.56) | SLC6A2SLC6A3SLC6A4CYP2D6KCNH2 | |
| Hydrochloric Acid SCHEMBL7000511 | 0.74 | SLC6A4 (0.54) | SLC6A2SLC6A3SLC6A4CYP2D6KCNH2 | |
| SCHEMBL3108178 | 0.74 | CCNT1 (0.40) | SLC6A2SLC6A3SLC6A4DPP4BACE1 | |
| SCHEMBL16585059 | 0.73 | BACE1 (0.39) | BACE1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL30232775 | 0.72 | SLC6A4 (0.46) | SLC6A2SLC6A3SLC6A4DPP4BACE1 | |
| SCHEMBL30232387 | 0.72 | SLC6A4 (0.46) | SLC6A2SLC6A3SLC6A4KCNH2DPP4 | |
| SCHEMBL3119870 | 0.72 | BACE1 (0.36) | SLC6A2SLC6A3SLC6A4CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329392-B1 | ANTIALLERGENS | AVENTIS PHARMACEUTICALS, INC. | 2001-12-11 | — | — | US | disclosed |
| EP-0777666-B1 | SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | MERRELL PHARMA INC (US) | 1999-03-03 | — | — | EP | disclosed |
| EP-0777666-A1 | NOVEL SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | MERRELL PHARMACEUTICALS INC. (US) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996006094-A1 | NOVEL SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | MERRELL PHARMACEUTICALS INC. (US) | 1996-02-29 | — | — | WO | disclosed |