Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 9/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | NEK7 | Q8TDX7 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962924 | 1.00 | ALDH1A1 (0.39) | ALDH1A1GLASMN1; SMN2PDE4AKCNH2 | |
| SCHEMBL7946366 | 0.87 | PDE4A (0.37) | ALDH1A1PDE4AKCNH2S1PR1S1PR3 | |
| SCHEMBL7954717 | 0.86 | S1PR1 (0.38) | PDE4AKCNH2S1PR1S1PR3PDE4B | |
| SCHEMBL8137726 | 0.86 | S1PR1 (0.38) | PDE4AKCNH2S1PR1S1PR3PDE4B | |
| SCHEMBL7966410 | 0.85 | PDE4A (0.37) | PDE4AKCNH2S1PR1S1PR3PDE4B | |
| SCHEMBL7953503 | 0.85 | PDE4A (0.37) | PDE4AKCNH2S1PR1S1PR3PDE4B | |
| SCHEMBL7951680 | 0.85 | CNR1 (0.43) | SMN1; SMN2PDE4AKCNH2S1PR1S1PR3 | |
| SCHEMBL7951678 | 0.85 | CNR1 (0.43) | SMN1; SMN2PDE4AKCNH2S1PR1S1PR3 | |
| SCHEMBL7960402 | 0.85 | PDE4A (0.43) | SMN1; SMN2PDE4AKCNH2S1PR1S1PR3 | |
| SCHEMBL7955415 | 0.85 | PDE4A (0.43) | SMN1; SMN2PDE4AKCNH2S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |