⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1418563 | 0.67 | — | — | |
| SCHEMBL3376530 | 0.67 | — | — | |
| SCHEMBL9624300 | 0.67 | — | — | |
| SCHEMBL4558001 | 0.67 | — | — | |
| SCHEMBL15766332 | 0.67 | — | — | |
| SCHEMBL477205 | 0.67 | — | — | |
| SCHEMBL2792441 | 0.63 | — | — | |
| SCHEMBL4724879 | 0.62 | — | — | |
| SCHEMBL4720204 | 0.62 | — | — | |
| SCHEMBL4917531 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10112958-B2 | N-[2-(2-amino-6,6-disubstituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-YL)-1,3-thiazol-4-YL] amides | PFIZER INC. (US) | 2018-10-30 | — | — | US | disclosed |
| EP-3353183-A1 | N-[2-(2-AMINO-6,6-DISUBSTITUTED-4, 4A, 5, 6-TETRAHYDROPYRANO [3,4-D][1,3]THIAZIN-8A (8H)-YL) -1, 3-THIAZOL-4-YL]AMIDES | Pfizer Inc (US) | 2018-08-01 | — | — | EP | disclosed |
| US-10028962-B2 | 2-amino-6-methy1-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides | PFIZER INC. (US) | 2018-07-24 | — | — | US | disclosed |
| US-20170305931-A1 | N-[2-(2-AMINO-6,6-DISUBSTITUTED-4,4a,5,6-TETRAHYDROPYRANO[3,4-d][1,3]THIAZIN-8a(8H)-YL)-1,3-THIAZOL-4-YL] AMIDES | PFIZER INC. (US) | 2017-10-26 | — | — | US | disclosed |
| US-20170304312-A1 | 2-Amino-6-Methyl-4,4a,5,6-Tetrahydropyrano[3,4-d][1,3]Thiazin-8a(8H)-yl-1,3-Thiazol-4-yl Amides | PFIZER INC. (US) | 2017-10-26 | — | — | US | disclosed |
| US-9751895-B2 | N-[2-(2-amino-6,6-disubstituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)-1,3-thiazol-4-yl]amides | PFIZER INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-9744173-B2 | 2-amino 6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides | PFIZER INC. (US) | 2017-08-29 | — | — | US | disclosed |
| CN-107108626-A | The purposes of azoles and naphthalene compound, the composition comprising these compounds and its controlling invertebrate pests | 巴斯夫欧洲公司 | 2017-08-29 | — | — | CN | disclosed |
| EP-2956458-B1 | HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO[3,4-D][1,3]THIAZIN-2-AMINE COMPOUNDS | PFIZER (US) | 2017-08-09 | — | — | EP | disclosed |
| EP-2956459-B1 | SUBSTITUTED PHENYL-HEXAHYDROPYRANO[3,4-D][1,3]THIAZIN-2-AMINE COMPOUNDS | PFIZER (US) | 2017-07-19 | — | — | EP | disclosed |
| WO-2014097038-A1 | CARBOCYCLIC- AND HETEROCYCLIC-SUBSTITUTED HEXAHYDROPYRANO[3,4-d][1,3]THIAZIN-2-AMINE COMPOUNDS | PFIZER INC. (US) | 2014-06-26 | — | — | WO | disclosed |
| WO-2014091352-A1 | HEXAHYDROPYRANO [3,4-D][1,3]THIAZIN-2-AMINE COMPOUNDS AS INHIBITORS OF BACE1 | PFIZER INC. (US) | 2014-06-19 | — | — | WO | disclosed |
| US-20140163015-A1 | HEXAHYDROPYRANO[3,4-d][1,3]THIAZIN-2-AMINE COMPOUNDS | PFIZER INC. (US) | 2014-06-12 | — | — | US | disclosed |
| WO-2014045162-A1 | ALKYL-SUBSTITUTED HEXAHYDROPYRANO[3,4-d] [1,3]THIAZIN-2-ANIME COMPOUNDS | PFIZER INC. (US) | 2014-03-27 | — | — | WO | disclosed |
| WO-2013164730-A1 | HETEROCYCLIC SUBSTITUTED HEXAHYDROPYRANO [3,4-D] [1,3] THIAZIN- 2 -AMINE COMPOUNDS AS INHIBITORS OF APP, BACE1 AND BACE 2. | PFIZER INC. (US) | 2013-11-07 | — | — | WO | disclosed |
| US-20130296308-A1 | Heterocyclic Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds | PFIZER INC. (US) | 2013-11-07 | — | — | US | disclosed |
| US-6303638-B1 | FOR THERAPY OF CENTRAL NERVOUS SYSTEM (CNS) DISORDERS, INCLUDING ALZHEIMER'S DISEASE, TOURETTE'S SYNDROME, COGNITIVE DYSFUNCTION E.G., DISORDERS OF ATTENTION, FOCUS AND CONCENTRATION, SUCH AS ATTENTION DEFICIT DISORDER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-10-16 | — | — | US | disclosed |
| US-4054652-A | ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1977-10-18 | — | — | US | disclosed |
| US-4054652-A | ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1977-10-18 | — | — | US | disclosed |
| US-4054652-A | ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1977-10-18 | — | — | US | disclosed |