Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 8/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8603547 | 0.90 | MKNK1 (0.38) | CYP11B2P2RX7CYP11B1CYP2A6CYP2C9 | |
| SCHEMBL7953077 | 0.89 | MKNK1 (0.40) | CYP11B2P2RX7KCNH2 | |
| SCHEMBL7954753 | 0.88 | NR4A2 (0.41) | CYP11B2P2RX7CYP11B1MAPK1 | |
| SCHEMBL7963731 | 0.87 | CYP11B2 (0.39) | CYP11B2P2RX7CYP11B1CYP2A6CYP3A4 | |
| SCHEMBL7963276 | 0.82 | CYP11B2 (0.39) | CYP11B2P2RX7CYP11B1CYP2A6CYP3A4 | |
| SCHEMBL7954864 | 0.79 | CYP11B2 (0.42) | CYP11B2P2RX7CYP11B1CYP2A6CYP3A4 | |
| SCHEMBL8330546 | 0.78 | CYP11B2 (0.37) | CYP11B2P2RX7CYP11B1CYP3A4CYP17A1 | |
| SCHEMBL7967737 | 0.78 | MKNK1 (0.39) | CYP11B2P2RX7KCNH2 | |
| SCHEMBL7961290 | 0.78 | DHODH (0.33) | P2RX7 | |
| SCHEMBL7592502 | 0.78 | CYP11B2 (0.42) | CYP11B2CYP11B1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |