Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8647218 | 0.88 | ABCC1 (0.42) | ABCC1CYP11B2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL7954913 | 0.85 | ABCC1 (0.41) | ABCC1CYP11B2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL7587234 | 0.85 | ABCC1 (0.44) | ABCC1CYP11B2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL7590017 | 0.84 | CYP11B2 (0.44) | ABCC1CYP11B2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL7954850 | 0.83 | ABCC1 (0.43) | ABCC1CYP11B2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL2158205 | 0.82 | KDM4E (0.45) | ABCC1CYP11B2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL7953813 | 0.82 | ABCC1 (0.43) | ABCC1CYP11B2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL7953497 | 0.81 | CYP11B2 (0.42) | ABCC1CYP11B2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL7953612 | 0.81 | ABCC1 (0.41) | ABCC1CYP11B2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL7946473 | 0.79 | ABCC1 (0.43) | ABCC1CYP11B2ALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | claimed |
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |