Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 4/20 | 0.32 |
| ▸ | MMP3 | P08254 | 4/20 | 0.32 |
| ▸ | MMP7 | P09237 | 3/20 | 0.32 |
| ▸ | MMP1 | P03956 | 4/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 2/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | MMP14 | P50281 | 1/20 | 0.31 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.31 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955106 | 1.00 | ADAM17 (0.43) | ADAM17CTRB1MMP2MMP3MMP7 | |
| SCHEMBL7955110 | 1.00 | ADAM17 (0.43) | ADAM17CTRB1MMP2MMP3MMP7 | |
| SCHEMBL7955115 | 1.00 | ADAM17 (0.43) | ADAM17CTRB1MMP2MMP3MMP7 | |
| SCHEMBL7840713 | 0.89 | ADAM17 (0.41) | ADAM17CTRB1MMP2MMP3MMP7 | |
| SCHEMBL7840708 | 0.89 | ADAM17 (0.41) | ADAM17CTRB1MMP2MMP3MMP7 | |
| SCHEMBL7840710 | 0.89 | ADAM17 (0.41) | ADAM17CTRB1MMP2MMP3MMP7 | |
| SCHEMBL7957360 | 0.88 | ADAM17 (0.54) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL7957351 | 0.88 | ADAM17 (0.54) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL7957354 | 0.88 | ADAM17 (0.54) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL7957357 | 0.88 | ADAM17 (0.54) | ADAM17MMP2MMP3MMP7MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |