Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | BACE1 | P56817 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7959785 | 0.92 | KDM4E (0.67) | LTA4HKDM4ESMN1; SMN2ALDH1A1HTT | |
| SCHEMBL3470265 | 0.88 | HRH3 (0.71) | KDM4EALDH1A1L3MBTL1TSHRHRH3 | |
| SCHEMBL7954345 | 0.88 | KMT2A (0.68) | LTA4HKDM4ESMN1; SMN2ALDH1A1BACE1 | |
| SCHEMBL2463808 | 0.86 | KDM4E (0.61) | LTA4HKDM4ESMN1; SMN2ALDH1A1HTT | |
| SCHEMBL31475230 | 0.81 | KDM4E (0.82) | LTA4HKDM4ESMN1; SMN2ALDH1A1BACE1 | |
| SCHEMBL18483417 | 0.81 | LTA4H (0.66) | LTA4HKDM4ESMN1; SMN2ALDH1A1BACE1 | |
| SCHEMBL4518005 | 0.81 | LTA4H (0.66) | LTA4HKDM4ESMN1; SMN2ALDH1A1BACE1 | |
| SCHEMBL8361480 | 0.81 | KDM4E (0.83) | LTA4HKDM4ESMN1; SMN2ALDH1A1BACE1 | |
| SCHEMBL264157 | 0.81 | LTA4H (0.81) | LTA4HKDM4ESMN1; SMN2ALDH1A1BACE1 | |
| SCHEMBL265398 | 0.81 | KDM4E (0.82) | LTA4HKDM4ESMN1; SMN2ALDH1A1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297274-B1 | SUBSTITUTED 5-HYDROXYFURANONES | WARNER-LAMBERT COMPANY | 2001-10-02 | — | — | US | claimed |
| WO-1997037985-A1 | NONPEPTIDE ENDOTHELIN ANTAGONISTS WITH INCREASED WATER SOLUBILITY | WARNER-LAMBERT COMPANY (US) | 1997-10-16 | — | — | WO | claimed |
| US-6297274-B1 | SUBSTITUTED 5-HYDROXYFURANONES | WARNER-LAMBERT COMPANY | 2001-10-02 | — | — | US | disclosed |
| WO-1997037985-A1 | NONPEPTIDE ENDOTHELIN ANTAGONISTS WITH INCREASED WATER SOLUBILITY | WARNER-LAMBERT COMPANY (US) | 1997-10-16 | — | — | WO | disclosed |