SCHEMBL7955211

SCHEMBL7955211

CCOC(=O)/C=C/c1ccccc1CBr

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.49
CA1 P00915 1/20 0.49
CA2 P00918 1/20 0.49
CA7 P43166 1/20 0.49
CA9 Q16790 1/20 0.49
CA14 Q9ULX7 1/20 0.49
KDM4E B2RXH2 2/20 0.46
ALDH1A1 P00352 1/20 0.46
HPGD P15428 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
TTR P02766 1/20 0.46
DPP4 P27487 1/20 0.46
CYP3A4 P08684 2/20 0.44
CCNC P24863 1/20 0.44
CDK8 P49336 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
MAPT P10636 4/20 0.43
LMNA P02545 1/20 0.43
MDM2 Q00987 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7955214 1.00 CA12 (0.49) CA12CA1CA2CA7CA9
SCHEMBL19780722 0.86 CA12 (0.50) CA12CA1CA2CA7CA9
SCHEMBL10783189 0.85 CA12 (0.59) CA12CA1CA2CA7CA9
SCHEMBL24611343 0.85 CA12 (0.49) CA12CA1CA2CA7CA9
SCHEMBL15631935 0.85 CA12 (0.49) CA12CA1CA2CA7CA9
SCHEMBL6821249 0.84 NFE2L2 (0.47) CA12CA1CA2CA7CA9
SCHEMBL6821253 0.84 NFE2L2 (0.47) CA12CA1CA2CA7CA9
SCHEMBL11054639 0.84 CA12 (0.57) CA12CA1CA2CA7CA9
SCHEMBL7399960 0.84 CA12 (0.48) CA12CA1CA2CA7CA9
SCHEMBL7836085 0.84 CA12 (0.51) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109896684-B Sewage pretreatment process in organic product preparation process 李德祥 2021-12-24 CN claimed
CN-109896684-B Sewage pretreatment process in organic product preparation process 李德祥 2021-12-24 CN disclosed
US-6211197-B1 CARBOXYLIC ACID OR TETRAZOLE DERIVATES; ANALGESICS, ANTIPYRETICS, AND ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION MERCK FROSST CANADA & CO. (CA) 2001-04-03 US disclosed
EP-0138504-B1 STEROID DERIVATIVES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-07-20 EP disclosed
US-4659516-A ANTIESTROGENS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-04-21 US disclosed
US-4568688-A SYMPATHOMIMETIC VASOCONSTRICTOR EFFECT BEIERSDORF AKTIENGESELLSCHAFT (DE) 1986-02-04 US disclosed
EP-0138504-A2 Steroid derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1985-04-24 EP disclosed
US-4175203-A TREATMENT OF RENAL FAILURE AND TRANSPLANT REJECTION VASODILATORS MERCK & CO., INC. (US) 1979-11-20 US disclosed
US-4150235-A ANTIBODY INHIBITORS, HYPOTENSIVE AGENTS, DIURETICS, VASODILATOR MERCK & CO., INC. (US) 1979-04-17 US disclosed
US-4140861-A RENAL DISFUNCTION, ANTIBODY INHIBITORS MERCK & CO., INC. (US) 1979-02-20 US disclosed