Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | TOP2A | P11388 | 3/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM6A | O15550 | 1/20 | 0.36 |
| ▸ | TET3 | O43151 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM4B | O94953 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960307 | 0.86 | KDM4E (0.55) | KDM4ETOP2ATOP2BPIK3CGGSK3B | |
| SCHEMBL7955441 | 0.85 | ELANE (0.49) | KDM4ETYK2ALDH1A1GAAHPGD | |
| SCHEMBL7964066 | 0.85 | CNR1 (0.46) | TYK2PKMPDE4AKCNH2 | |
| SCHEMBL7951788 | 0.84 | KDM4E (0.60) | KDM4ETOP2ATOP2BALDH1A1GAA | |
| SCHEMBL7946345 | 0.84 | KDM4E (0.63) | KDM4ETOP2ATOP2BALDH1A1GAA | |
| SCHEMBL7953294 | 0.83 | KDM4E (0.65) | KDM4ETOP2ATOP2BALDH1A1GAA | |
| SCHEMBL7963122 | 0.82 | KDM4E (0.51) | KDM4ETOP2ATOP2BPIK3CGGSK3B | |
| SCHEMBL7963124 | 0.82 | KDM4E (0.51) | KDM4ETOP2ATOP2BPIK3CGGSK3B | |
| SCHEMBL7954825 | 0.81 | KDM4E (0.46) | KDM4ETYK2TOP2ATOP2BPIK3CG | |
| SCHEMBL7946367 | 0.81 | KDM4E (0.46) | KDM4ETYK2TOP2ATOP2BPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |