Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.50 |
| ▸ | PPARG | P37231 | 3/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955771 | 1.00 | PPARA (0.50) | PPARAPPARGCYP17A1CTSSADAMTS4 | |
| SCHEMBL4184785 | 0.84 | CYP17A1 (0.52) | PPARAPPARGCYP17A1PTGDR2DRD2 | |
| SCHEMBL34480 | 0.78 | CYP17A1 (0.59) | PPARAPPARGCYP17A1PTGDR2DRD2 | |
| SCHEMBL16856562 | 0.78 | CYP17A1 (0.53) | PPARAPPARGCYP17A1PTGDR2DRD2 | |
| SCHEMBL20204187 | 0.78 | CYP17A1 (0.53) | PPARAPPARGCYP17A1PTGDR2DRD2 | |
| SCHEMBL31739363 | 0.78 | CYP17A1 (0.48) | PPARAPPARGCYP17A1ADAMTS4PTGDR2 | |
| SCHEMBL7605437 | 0.77 | CYP17A1 (0.49) | PPARAPPARGCYP17A1PTGDR2DRD2 | |
| SCHEMBL28747809 | 0.77 | PPARG (0.50) | PPARAPPARGCYP17A1ADAMTS4PTGDR2 | |
| SCHEMBL27577525 | 0.77 | PPARG (0.50) | PPARAPPARGCYP17A1ADAMTS4PTGDR2 | |
| Hydrochloric Acid SCHEMBL7420599 | 0.77 | CYP17A1 (0.58) | PPARAPPARGCYP17A1PTGDR2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274715-B1 | SEMISYNTHETIC MACROLIDES, USEFUL IN BACTERIAL INFECTIONS TREATMENT AND PREVENTION, HAS LESS POTENTIAL FOR DEVELOPING RESISTANCE, IMPROVED OR MODIFIED PROFILES OF DESIRED GRAM-NEGATIVE ACTIVITY | ABBOTT LABORATORIES | 2001-08-14 | — | — | US | disclosed |
| EP-0961776-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | Abbott Laboratories (US) | 1999-12-08 | — | — | EP | disclosed |
| WO-1998030574-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1998-07-16 | — | — | WO | disclosed |