Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NAMPT | P43490 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953774 | 0.86 | POLB (0.60) | RAB9ANPC1SMN1; SMN2GAAKMT2A | |
| SCHEMBL3039047 | 0.85 | RAB9A (0.62) | RAB9ANPC1SMN1; SMN2GAAKMT2A | |
| SCHEMBL483578 | 0.84 | RAB9A (0.74) | RAB9ANPC1SMN1; SMN2GAAKMT2A | |
| SCHEMBL4626846 | 0.84 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2GAAKMT2A | |
| SCHEMBL7958940 | 0.80 | SMN1; SMN2 (0.58) | RAB9ANPC1SMN1; SMN2GAAKMT2A | |
| SCHEMBL6500425 | 0.77 | RAB9A (0.65) | RAB9ANPC1SMN1; SMN2GAAKMT2A | |
| SCHEMBL11666172 | 0.77 | CNR1 (0.67) | RAB9ANPC1SMN1; SMN2GAAKMT2A | |
| SCHEMBL1394203 | 0.77 | RAB9A (0.74) | RAB9ANPC1SMN1; SMN2GAAKMT2A | |
| SCHEMBL13947349 | 0.77 | RAB9A (0.65) | RAB9ANPC1SMN1; SMN2GAAKMT2A | |
| SCHEMBL3775207 | 0.76 | RAB9A (0.63) | RAB9ANPC1SMN1; SMN2GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235758-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-22 | — | — | US | disclosed |
| EP-0808312-B1 | INDOLE DERIVATIVES AS 5-HT RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM PLC (GB) | 2000-11-02 | — | — | EP | disclosed |
| US-5990133-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS ANXIETY OR DEPRESSION | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |