Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.55 |
| ▸ | CDC7 | O00311 | 7/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.55 |
| ▸ | DBF4 | Q9UBU7 | 7/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.45 |
| ▸ | CLK1 | P49759 | 3/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | FES | P07332 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957150 | 0.86 | CDC7 (0.54) | CDK2CDC7CCNE1DBF4DYRK1A | |
| SCHEMBL1557178 | 0.86 | CDC7 (0.74) | CDK2CDC7CCNE1DBF4DYRK1A | |
| SCHEMBL16976914 | 0.85 | CDC7 (0.53) | CDK2CDC7CCNE1DBF4DYRK1A | |
| SCHEMBL27680371 | 0.74 | KIT (0.67) | CDK2DYRK1ACLK1FGFR1PLK4 | |
| SCHEMBL878730 | 0.73 | FGFR1 (0.69) | CDK2DYRK1AFGFR1PLK4AURKA | |
| SCHEMBL31326317 | 0.73 | KMT2A (0.64) | FGFR1FGFR4 | |
| SCHEMBL14377770 | 0.73 | PIM1 (0.50) | CDK2CDC7CCNE1DBF4PIM1 | |
| SCHEMBL2190120 | 0.72 | CDC7 (0.47) | CDK2CDC7CCNE1DBF4ROCK2 | |
| SCHEMBL2189331 | 0.72 | CDC7 (0.47) | CDK2CDC7CCNE1DBF4ROCK2 | |
| SCHEMBL15257736 | 0.72 | CDK2 (0.46) | CDK2CDC7CCNE1DBF4DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466170-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2013-06-18 | — | — | US | disclosed |
| EP-2303879-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-09-05 | — | — | EP | disclosed |
| US-20110166175-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-07-07 | — | — | US | disclosed |
| WO-2010020308-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166175-A1 | 7-AZAINDOLE DERIVATIVES | JAK3, AZI2, MYLK2 | CDK2 111/4885CDC7 250/4885CCNE1 187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.