Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 7/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.53 |
| ▸ | CDK2 | P24941 | 7/20 | 0.53 |
| ▸ | DBF4 | Q9UBU7 | 7/20 | 0.53 |
| ▸ | CLK1 | P49759 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957150 | 0.87 | CDC7 (0.54) | CDC7CCNE1CDK2DBF4CLK1 | |
| SCHEMBL7955873 | 0.85 | CDK2 (0.55) | CDC7CCNE1CDK2DBF4CLK1 | |
| SCHEMBL1557178 | 0.82 | CDC7 (0.74) | CDC7CCNE1CDK2DBF4DYRK1A | |
| SCHEMBL14377770 | 0.75 | PIM1 (0.50) | CDC7CCNE1CDK2DBF4PIM1 | |
| SCHEMBL14335342 | 0.73 | CDC7 (0.65) | CDC7CCNE1CDK2DBF4 | |
| SCHEMBL14378024 | 0.72 | ALK (0.61) | CDC7CCNE1CDK2DBF4 | |
| SCHEMBL7946423 | 0.69 | CDC7 (1.00) | CDC7CCNE1CDK2DBF4CLK1 | |
| SCHEMBL14377091 | 0.69 | CDC7 (0.66) | CDC7CCNE1CDK2DBF4 | |
| SCHEMBL14377766 | 0.69 | RIPK1 (0.47) | NTRK1KITNEK1 | |
| SCHEMBL12506950 | 0.69 | CDC7 (0.74) | CDC7CCNE1CDK2DBF4DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2723736-B1 | 7-Azaindole derivatives suitable for the treatment of cancers | MERCK PATENT GMBH (DE) | 2015-08-05 | — | — | EP | disclosed |