SCHEMBL7955933

SCHEMBL7955933

Clc1ccc(C2=CC3CCC2N3)cn1

nearest known ligand 0.97

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 8/20 0.58
CHRNA4 P43681 7/20 0.58
CHRNA7 P36544 5/20 0.58
CHRNA3 P32297 4/20 0.58
ALDH1A1 P00352 3/20 0.58
MEN1 O00255 2/20 0.58
KMT2A Q03164 2/20 0.58
TDP1 Q9NUW8 2/20 0.58
CYP1A2 P05177 1/20 0.58
CYP3A4 P08684 1/20 0.58
ALOX15 P16050 1/20 0.58
HSD17B10 Q99714 1/20 0.58
CHRNB4 P30926 3/20 0.41
CHRNA1 P02708 1/20 0.41
CHRNG P07510 1/20 0.41
CHRNB1 P11230 1/20 0.41
HPGD P15428 1/20 0.41
CHRND Q07001 1/20 0.41
CHRNA2 Q15822 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24154667 0.75 CHRNB2 (0.43) CHRNB2CHRNA4CHRNA7CHRNA3ALDH1A1
SCHEMBL7757337 0.74 CHRNB2 (1.00) CHRNB2CHRNA4CHRNA7CHRNA3ALDH1A1
Hydrochloric Acid SCHEMBL30116802 0.74 CHRNB2 (0.42) CHRNB2CHRNA4CHRNA7CHRNA3ALDH1A1
Hydrochloric Acid SCHEMBL25307426 0.74 CHRNB2 (0.42) CHRNB2CHRNA4CHRNA7CHRNA3ALDH1A1
SCHEMBL2081322 0.72 CHRNB2 (0.43) CHRNB2CHRNA4CHRNA7CHRNA3ALDH1A1
SCHEMBL2082312 0.72 CHRNB2 (0.46) CHRNB2CHRNA4CHRNA7CHRNA3ALDH1A1
SCHEMBL20401781 0.70 CHRNB2 (0.57) CHRNB2CHRNA4CHRNA7CHRNA3ALDH1A1
SCHEMBL1662273 0.67 PIK3CD (0.73) CHRNB2CHRNA4CHRNA7CHRNA3ALDH1A1
SCHEMBL2080719 0.65 CHRNB2 (0.51) CHRNB2CHRNA4CHRNA7CHRNA3ALDH1A1
SCHEMBL2081684 0.64 CHRNB2 (0.56) CHRNB2CHRNA4CHRNA7CHRNA3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6255490-B1 TREATING DISORDERS ASSOCIATED WITH CHANGES IN CHOLINERGIC ACTIVITY; NON-OPIATE BASED ANALGESIC FOR MODERATE TO SEVERE PAIN EQUALLY OR EXCEEDING THE POTENCY OF OPIATE ANALGESICS, YET LACKING ADDICTIVE SIDE EFFECTS UNIVERSITY OF VIRGINIA 2001-07-03 US disclosed
US-6117889-A 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents UNIVERSITY OF VIRGINIA (US) 2000-09-12 US disclosed
US-6060473-A 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands UCB S.A. - DTB (BE) 2000-05-09 US disclosed
WO-1996006093-A1 7-AZABICYCLO[2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS CHOLINERGIC RECEPTOR LIGANDS UNIVERSITY OF VIRGINIA (US) 1996-02-29 WO disclosed
EP-0691971-A1 7-AZABICYCLO- 2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS ANALGESICS AND ANTI-INFLAMMATORY AGENTS UNIVERSITY OF VIRGINIA (US) 1996-01-17 EP disclosed
WO-1994022868-A1 7-AZABICYCLO-[2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS ANALGESICS AND ANTI-INFLAMMATORY AGENTS UNIVERSITY OF VIRGINIA (US) 1994-10-13 WO disclosed