Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.34 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956085 | 1.00 | ALDH1A1 (0.39) | ALDH1A1PDE3BPDE3AMAPK1KMT2A | |
| SCHEMBL7954141 | 0.80 | MAPK1 (0.52) | ALDH1A1PDE3BPDE3AMAPK1KMT2A | |
| SCHEMBL7946959 | 0.78 | MAPK1 (0.47) | ALDH1A1PDE3BPDE3AMAPK1KMT2A | |
| SCHEMBL7946984 | 0.77 | PDE3B (0.45) | ALDH1A1PDE3BPDE3AMAPK1KMT2A | |
| SCHEMBL7958065 | 0.76 | ALDH1A1 (0.44) | ALDH1A1PDE3BPDE3AMAPK1KMT2A | |
| SCHEMBL7955863 | 0.75 | ALDH1A1 (0.41) | ALDH1A1PDE3BPDE3AMAPK1KMT2A | |
| SCHEMBL7955763 | 0.74 | ALDH1A1 (0.41) | ALDH1A1PDE3BPDE3AMAPK1KMT2A | |
| SCHEMBL7954495 | 0.74 | ALDH1A1 (0.40) | ALDH1A1PDE3BPDE3AMAPK1KMT2A | |
| SCHEMBL21869100 | 0.71 | ALDH1A1 (0.42) | ALDH1A1PDE3BPDE3AMAPK1KMT2A | |
| SCHEMBL7873755 | 0.70 | ESR1 (0.44) | ALDH1A1MAPK1GAAMAPTCYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271251-B1 | CARDIOVASCULAR DISORDERS | SUMITOMO PHARMACEUTICALS COMPANY LIMITED (JP) | 2001-08-07 | — | — | US | disclosed |
| US-5977100-A | Substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| EP-0787728-A1 | Substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-08-06 | — | — | EP | disclosed |