Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | CHKA | P35790 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3440028 | 0.80 | CHKA (0.48) | CNR2CHKAMAPTKDM4ENPC1 | |
| SCHEMBL7956825 | 0.80 | AKR1C3 (0.54) | CHKAAKR1C3MAPTKDM4ENPC1 | |
| SCHEMBL16695272 | 0.78 | CNR2 (0.73) | GPR119CNR2MAPTNPSR1DRD2 | |
| SCHEMBL972745 | 0.77 | CNR2 (0.54) | GPR119CNR2RAB9ADRD2DRD4 | |
| SCHEMBL3911609 | 0.77 | CNR2 (0.64) | CNR2MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL6125262 | 0.77 | KMT2A (0.58) | GPR119CNR2RAB9ADRD2DRD4 | |
| SCHEMBL29656785 | 0.77 | CNR2 (0.76) | GPR119CNR2MAPTNPSR1DRD2 | |
| SCHEMBL7956433 | 0.76 | MAPT (0.64) | GPR119MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL28112415 | 0.75 | CHKA (0.80) | CHKAAKR1C3TRPV1MAPTKDM4E | |
| SCHEMBL1998095 | 0.75 | CNR2 (0.55) | GPR119CNR2MAPTKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |