Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | DRD4 | P21917 | 5/20 | 0.72 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.72 |
| ▸ | HTR7 | P34969 | 3/20 | 0.72 |
| ▸ | HTR2B | P41595 | 3/20 | 0.72 |
| ▸ | HTR2A | P28223 | 2/20 | 0.72 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | HTR1B | P28222 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947512 | 0.87 | HTR1A (0.66) | HTR1AADRA1ASMN1; SMN2DRD4ADRA1B | |
| SCHEMBL7955208 | 0.87 | HTR1A (0.66) | HTR1AADRA1ASMN1; SMN2DRD4ADRA1B | |
| SCHEMBL8013725 | 0.85 | HTR1A (1.00) | HTR1AADRA1ASMN1; SMN2DRD4ADRA1B | |
| Hydrochloric Acid SCHEMBL29989604 | 0.84 | HTR1A (0.98) | HTR1AADRA1ASMN1; SMN2DRD4ADRA1B | |
| SCHEMBL8010894 | 0.84 | HTR1A (1.00) | HTR1AADRA1ASMN1; SMN2DRD4ADRA1B | |
| SCHEMBL7955216 | 0.84 | HTR1A (0.61) | HTR1AADRA1ASMN1; SMN2DRD4ADRA1B | |
| SCHEMBL7959023 | 0.83 | HTR1A (0.78) | HTR1AADRA1ASMN1; SMN2DRD4ADRA1B | |
| SCHEMBL7956950 | 0.83 | HTR1A (0.78) | HTR1AADRA1ASMN1; SMN2DRD4ADRA1B | |
| SCHEMBL8013349 | 0.82 | HTR1A (0.77) | HTR1AADRA1ASMN1; SMN2DRD4ADRA1B | |
| Way-100,635 SCHEMBL13398069 | 0.82 | HTR1A (1.00) | HTR1AADRA1ASMN1; SMN2DRD4ADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000045-A1 | 1,4-DISUBSTITUTED PIPERAZINES | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 2000-05-17 | — | — | EP | claimed |
| WO-1999006382-A1 | 1,4-DISUBSTITUTED PIPERAZINES | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1999-02-11 | — | — | WO | claimed |
| US-6271234-B1 | DERIVATIVES WHICH BIND TO SEROTONERGIC RECEPTORS; TREATING DISORDERS OF THE LOWER URINARY TRACT | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2001-08-07 | — | — | US | disclosed |