Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 9/20 | 0.78 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960131 | 0.91 | NPY1R (0.79) | NPY1RSIGMAR1HRH3 | |
| SCHEMBL7958847 | 0.89 | NPY1R (0.74) | NPY1R | |
| SCHEMBL7963425 | 0.88 | NPY1R (1.00) | NPY1RALDH1A1HSD17B10HRH3 | |
| Hydrochloric Acid SCHEMBL7958491 | 0.88 | NPY1R (0.96) | NPY1RALDH1A1HSD17B10HRH3 | |
| SCHEMBL7960625 | 0.88 | NPY1R (0.83) | NPY1RKDM4EALDH1A1ALOX15SMN1; SMN2 | |
| SCHEMBL7959676 | 0.88 | NPY1R (0.76) | NPY1RHSD17B10HRH3 | |
| SCHEMBL7958627 | 0.87 | NPY1R (1.00) | NPY1RHRH3 | |
| Hydrochloric Acid SCHEMBL7956797 | 0.87 | NPY1R (0.98) | NPY1RALDH1A1HSD17B10HRH3 | |
| Hydrochloric Acid SCHEMBL7960187 | 0.86 | NPY1R (0.80) | NPY1RSIGMAR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7958759 | 0.85 | NPY1R (0.86) | NPY1RSIGMAR1SMN1; SMN2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245761-B1 | NERVOUS SYSTEM, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | ELI LILLY AND COMPANY | 2001-06-12 | — | — | US | disclosed |
| CN-1173867-A | Indolyl neuropeptide Y receptor antagonists | LILLY CO ELI (US) | 1998-02-18 | — | — | CN | disclosed |
| EP-0789688-A4 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-11-19 | — | — | EP | disclosed |
| EP-0789688-A1 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-08-20 | — | — | EP | disclosed |
| WO-1997009308-A1 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-03-13 | — | — | WO | disclosed |