Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17359704 | 0.81 | SLC6A2 (0.52) | LMNAKDM4EL3MBTL1AOC3TSHR | |
| SCHEMBL301347 | 0.78 | LMNA (0.44) | TACR1LMNAKDM4EL3MBTL1MAPK1 | |
| SCHEMBL246459 | 0.78 | LMNA (0.44) | TACR1LMNAKDM4EL3MBTL1MAPK1 | |
| SCHEMBL17593226 | 0.77 | LMNA (0.45) | LMNAKDM4EAOC3TSHRHTR2A | |
| SCHEMBL19340077 | 0.76 | TACR1 (0.43) | TACR1LMNAKDM4EL3MBTL1MAPK1 | |
| SCHEMBL11633696 | 0.76 | TAAR1 (0.54) | TACR1LMNAAOC3SLC6A2SLC6A4 | |
| SCHEMBL6489407 | 0.76 | TACR1 (0.43) | TACR1LMNAKDM4EL3MBTL1MAPK1 | |
| SCHEMBL13567490 | 0.76 | LMNA (0.60) | TACR1LMNAKDM4EL3MBTL1AOC3 | |
| SCHEMBL11635324 | 0.76 | TACR1 (0.43) | TACR1LMNAKDM4EL3MBTL1MAPK1 | |
| SCHEMBL245680 | 0.76 | CYP2C19 (0.53) | TACR1LMNAKDM4EL3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323235-B1 | CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS AND ENZYME INHIBITORS | OHTAKE ATSUSHI (JP) | 2001-11-27 | — | — | US | disclosed |
| US-6043264-A | A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA | TORAY INDUSTRIES, INC. (JP) | 2000-03-28 | — | — | US | disclosed |
| EP-0751126-A1 | BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME | TORAY INDUSTRIES, INC. (JP) | 1997-01-02 | — | — | EP | disclosed |