Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975299 | 0.86 | CYP2D6 (0.48) | CYP2D6MEN1KMT2ACYP2C9POLB | |
| Water SCHEMBL3089403 | 0.82 | CYP2D6 (0.70) | CCNA2CDK2CCNA1CYP2D6CYP2C9 | |
| SCHEMBL8018069 | 0.82 | CYP2D6 (0.53) | CYP2D6KMT2ACYP2C9GAANPC1 | |
| SCHEMBL7972839 | 0.82 | CYP2D6 (0.53) | CYP2D6MEN1KMT2ACYP2C9GAA | |
| SCHEMBL7975191 | 0.81 | CYP2D6 (0.57) | CYP2D6PDK1PDK2PDK3PDK4 | |
| SCHEMBL194951 | 0.81 | CYP2D6 (0.72) | CCNA2CDK2CCNA1CYP2D6CYP2C9 | |
| SCHEMBL14590778 | 0.80 | HTT (0.65) | CYP2D6KMT2ACYP2C9GAANPC1 | |
| SCHEMBL7968909 | 0.79 | CYP2D6 (0.50) | CYP2D6CYP2C9GAANPC1RAB9A | |
| SCHEMBL7970177 | 0.78 | PLK1 (0.50) | CYP2D6MEN1KMT2ACYP2C9POLB | |
| SCHEMBL7972482 | 0.78 | CYP2D6 (0.49) | CYP2D6POLBALDH1A1NAMPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291464-B1 | POTENTIATION OF THE CHOLINERGIC ACTIVITY; THERAPEUTIC TREATMENT OF AMNESIA, DEMENTIA OR SENILE DEMENTIA | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-09-18 | — | — | US | disclosed |
| EP-0968201-A2 | NEW AMINOPIPERAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998035951-A2 | NEW AMINOPIPERAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-08-20 | — | — | WO | disclosed |