Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 6/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1367400 | 0.88 | MAPT (0.56) | CFTRMAPTTDP1LMNASCN8A | |
| SCHEMBL1364802 | 0.81 | CFTR (0.64) | CFTRMAPTSCN8ASCN10ANPSR1 | |
| SCHEMBL31098224 | 0.79 | MAPT (0.62) | CFTRMAPTTDP1LMNAPOLB | |
| SCHEMBL1365207 | 0.79 | MAPT (0.71) | CFTRMAPTTDP1LMNAPOLB | |
| SCHEMBL12142560 | 0.76 | MAPT (0.58) | MAPTTDP1LMNASCN8ASCN10A | |
| SCHEMBL16302025 | 0.75 | SCN8A (0.53) | CFTRMAPTTDP1SCN8ASCN10A | |
| SCHEMBL24901813 | 0.75 | CFTR (0.67) | CFTRMAPTLMNAKDM4EUSP2 | |
| SCHEMBL24518270 | 0.75 | SCN10A (0.61) | CFTRSCN8ASCN10A | |
| SCHEMBL9118601 | 0.74 | MAPT (0.53) | CFTRMAPTTDP1LMNAPOLB | |
| SCHEMBL1365182 | 0.73 | CFTR (0.64) | CFTRMAPTTDP1LMNASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137499-A1 | INHIBITORS OF HISTONE DEACETYLASE | ENVIVO PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009137462-A2 | METHODS FOR TREATING COGNITIVE DISORDERS USING INHIBITORS OF HISTONE DEACETYLASE | ENVIVO PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |
| WO-2008055068-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2008-05-08 | — | — | WO | disclosed |