Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.48 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.48 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.48 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7959292 | 0.85 | GRIA1 (0.53) | KMT2AMEN1GRIA1GRIA2GRIA3 | |
| SCHEMBL7958054 | 0.83 | GRIA1 (0.56) | ALDH1A1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7959924 | 0.83 | GRIA1 (0.45) | ALDH1A1SMN1; SMN2KDM4EKMT2AMEN1 | |
| SCHEMBL7948364 | 0.82 | GRIA1 (0.49) | KMT2AGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7959487 | 0.82 | GRIA1 (0.47) | ALDH1A1SMN1; SMN2KDM4EKMT2AMEN1 | |
| SCHEMBL7948372 | 0.81 | GRIA1 (0.51) | ALDH1A1KMT2AMEN1GRIA1GRIA2 | |
| SCHEMBL7948140 | 0.81 | GRIA1 (0.48) | ALDH1A1KDM4EKMT2AMEN1GRIA1 | |
| SCHEMBL8894957 | 0.80 | GRIA1 (0.48) | ALDH1A1KDM4EKMT2AMEN1GRIA1 | |
| SCHEMBL7948349 | 0.80 | GRIA1 (0.48) | ALDH1A1SMN1; SMN2KDM4EKMT2AMEN1 | |
| SCHEMBL7957898 | 0.80 | GRIA1 (0.49) | ALDH1A1SMN1; SMN2KMT2AGRIA1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191134-B1 | STROKE THERAPY, ANTIISCHEMIC AGENTS, BRAIN DISORDERS | WARNER-LAMBERT COMPANY | 2001-02-20 | — | — | US | claimed |
| WO-1997046539-A1 | AMIDE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-12-11 | — | — | WO | claimed |
| US-6268366-B1 | Amide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists | WARNER-LAMBERT COMPANY | 2001-07-31 | — | — | US | disclosed |
| US-6191134-B1 | STROKE THERAPY, ANTIISCHEMIC AGENTS, BRAIN DISORDERS | WARNER-LAMBERT COMPANY | 2001-02-20 | — | — | US | disclosed |
| WO-1997046539-A1 | AMIDE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-12-11 | — | — | WO | disclosed |