Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.45 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7959292 | 0.84 | GRIA1 (0.53) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7959733 | 0.83 | ALDH1A1 (0.53) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL7948364 | 0.81 | GRIA1 (0.49) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7958054 | 0.80 | GRIA1 (0.56) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL7959487 | 0.79 | GRIA1 (0.47) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL7957879 | 0.78 | GRIA1 (0.51) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7948372 | 0.78 | GRIA1 (0.51) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL7960263 | 0.77 | GRIA1 (0.50) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL8894957 | 0.77 | GRIA1 (0.48) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL7957898 | 0.77 | GRIA1 (0.49) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191134-B1 | STROKE THERAPY, ANTIISCHEMIC AGENTS, BRAIN DISORDERS | WARNER-LAMBERT COMPANY | 2001-02-20 | — | — | US | claimed |
| US-6268366-B1 | Amide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists | WARNER-LAMBERT COMPANY | 2001-07-31 | — | — | US | disclosed |
| US-6191134-B1 | STROKE THERAPY, ANTIISCHEMIC AGENTS, BRAIN DISORDERS | WARNER-LAMBERT COMPANY | 2001-02-20 | — | — | US | disclosed |