Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 8/20 | 0.73 |
| ▸ | KDM1A | O60341 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9383867 | 1.00 | ALOX5 (0.73) | ALOX5KDM1ASMN1; SMN2NPSR1SLC9A1 | |
| SCHEMBL9381959 | 1.00 | ALOX5 (0.73) | ALOX5KDM1ASMN1; SMN2NPSR1SLC9A1 | |
| SCHEMBL7959761 | 1.00 | ALOX5 (0.73) | ALOX5KDM1ASMN1; SMN2NPSR1SLC9A1 | |
| SCHEMBL9380387 | 0.88 | ALOX5 (0.80) | ALOX5KDM1ANPSR1ALDH1A1 | |
| SCHEMBL9380392 | 0.88 | ALOX5 (0.80) | ALOX5KDM1ANPSR1ALDH1A1 | |
| SCHEMBL9380156 | 0.87 | ALOX5 (0.65) | ALOX5ALDH1A1 | |
| SCHEMBL9380154 | 0.87 | ALOX5 (0.65) | ALOX5ALDH1A1 | |
| SCHEMBL9380906 | 0.85 | ALOX5 (0.64) | ALOX5KDM1A | |
| SCHEMBL9380421 | 0.85 | ALOX5 (0.64) | ALOX5KDM1A | |
| SCHEMBL9381582 | 0.85 | ALOX5 (1.00) | ALOX5NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |