Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.53 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.33 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7959762 | 1.00 | ALOX5 (0.53) | ALOX5SLC9A1PARP10KDM1AKCNH2 | |
| SCHEMBL7971120 | 1.00 | ALOX5 (0.53) | ALOX5SLC9A1PARP10KDM1AKCNH2 | |
| SCHEMBL7971122 | 1.00 | ALOX5 (0.53) | ALOX5SLC9A1PARP10KDM1AKCNH2 | |
| SCHEMBL7959763 | 1.00 | ALOX5 (0.53) | ALOX5SLC9A1PARP10KDM1AKCNH2 | |
| SCHEMBL7972814 | 0.89 | ALOX5 (0.64) | ALOX5SLC9A1PARP10KDM1AKCNH2 | |
| SCHEMBL7959777 | 0.89 | ALOX5 (0.64) | ALOX5SLC9A1PARP10KDM1AKCNH2 | |
| SCHEMBL7959780 | 0.89 | ALOX5 (0.64) | ALOX5SLC9A1PARP10KDM1AKCNH2 | |
| SCHEMBL7973210 | 0.85 | HTR2C (0.43) | ALOX5TRPV1 | |
| SCHEMBL9198851 | 0.85 | HTR2C (0.43) | ALOX5TRPV1 | |
| SCHEMBL7973201 | 0.85 | HTR2C (0.43) | ALOX5TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5294921-A | — | — | None | — | — | JP | disclosed |
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |
| EP-0636119-A1 | PHENYL SUBSTITUTED CYCLOALKYL HYDROXYUREA DERIVATIVES WHICH INHIBIT LIPOXYGENASE | PFIZER INC. (US) | 1995-02-01 | — | — | EP | disclosed |
| JP-H05294921-A | NEW PHENYL-SUBSTITUTED CYCLOALKYLUREA DERIVATIVE AND COMPOSITION | PFIZER PHARMACEUT CO LTD | 1993-11-09 | — | — | JP | disclosed |
| WO-1993021149-A1 | PHENYL SUBSTITUTED CYCLOALKYL HYDROXYUREA DERIVATIVES WHICH INHIBIT LIPOXYGENASE | PFIZER INC. (US) | 1993-10-28 | — | — | WO | disclosed |