Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | NOS3 | P29474 | 1/20 | 0.50 |
| ▸ | NOS2 | P35228 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952162 | 0.83 | GAA (0.54) | GAAL3MBTL1THRBATMALDH1A1 | |
| SCHEMBL6954684 | 0.83 | GAA (0.54) | GAAL3MBTL1THRBATMALDH1A1 | |
| SCHEMBL1111736 | 0.79 | GAA (0.67) | GAAL3MBTL1THRBATMALDH1A1 | |
| SCHEMBL1267094 | 0.77 | GAA (0.65) | GAAL3MBTL1THRBATMALDH1A1 | |
| SCHEMBL1219954 | 0.77 | GAA (0.65) | GAAL3MBTL1THRBATMALDH1A1 | |
| SCHEMBL29588936 | 0.77 | GAA (0.65) | GAAL3MBTL1THRBATMALDH1A1 | |
| SCHEMBL3629079 | 0.77 | GAA (0.70) | GAAL3MBTL1THRBATMALDH1A1 | |
| SCHEMBL10985089 | 0.76 | ALDH1A1 (0.72) | GAAL3MBTL1THRBATMALDH1A1 | |
| SCHEMBL1684895 | 0.76 | — | — | |
| SCHEMBL382565 | 0.76 | GAA (0.68) | GAAL3MBTL1THRBATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271378-B1 | Process for preparing tricyclic compounds having antihistaminic activity | SCHERING CORPORATION | 2001-08-07 | — | — | US | disclosed |