Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 17/20 | 0.64 |
| ▸ | TBXA2R | P21731 | 11/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7958938 | 0.94 | PTGIR (0.69) | PTGIRTBXA2RKDM4EALDH1A1HPGD | |
| SCHEMBL7948871 | 0.91 | PTGIR (0.61) | PTGIRTBXA2RKDM4EALDH1A1HPGD | |
| SCHEMBL7956134 | 0.88 | PTGIR (0.73) | PTGIRTBXA2RKDM4EALDH1A1HPGD | |
| SCHEMBL7948745 | 0.85 | PTGIR (0.67) | PTGIRTBXA2RKDM4EALDH1A1HPGD | |
| SCHEMBL7958495 | 0.85 | PTGIR (0.59) | PTGIRTBXA2RKDM4EALDH1A1HPGD | |
| SCHEMBL7958406 | 0.84 | PTGIR (0.56) | PTGIRTBXA2RPSMB8PSMB5HTR1A | |
| SCHEMBL7958534 | 0.83 | PTGIR (0.56) | PTGIRTBXA2RPSMB8PSMB5HTR1A | |
| SCHEMBL7958773 | 0.82 | PTGIR (0.59) | PTGIRTBXA2RKDM4EALDH1A1HPGD | |
| SCHEMBL7956750 | 0.82 | PTGIR (0.61) | PTGIRTBXA2RKDM4EALDH1A1HPGD | |
| SCHEMBL7958476 | 0.81 | PTGIR (0.60) | PTGIRTBXA2RKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323235-B1 | CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS AND ENZYME INHIBITORS | OHTAKE ATSUSHI (JP) | 2001-11-27 | — | — | US | disclosed |
| US-6043264-A | A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA | TORAY INDUSTRIES, INC. (JP) | 2000-03-28 | — | — | US | disclosed |
| EP-0751126-A1 | BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME | TORAY INDUSTRIES, INC. (JP) | 1997-01-02 | — | — | EP | disclosed |