SCHEMBL7960288

SCHEMBL7960288

O=C(COCCc1coc2c(O)cccc12)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGIR P43119 10/20 0.40
TBXA2R P21731 7/20 0.40
ESR1 P03372 2/20 0.39
ESR2 Q92731 2/20 0.39
MEN1 O00255 2/20 0.37
MAPT P10636 2/20 0.37
KMT2A Q03164 2/20 0.37
JAK2 O60674 1/20 0.37
USP2 O75604 1/20 0.37
GAA P10253 1/20 0.37
ALOX15 P16050 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
HSD17B10 Q99714 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C19 P33261 1/20 0.37
TYR P14679 1/20 0.35
KDM4E B2RXH2 1/20 0.35
NPC1 O15118 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7958476 0.84 PTGIR (0.60) PTGIRTBXA2RMEN1KMT2ASMN1; SMN2
SCHEMBL7960429 0.80 DAO (0.40) PTGIRTBXA2RMAPTSMN1; SMN2KDM4E
SCHEMBL7958811 0.78 MEN1 (0.41) PTGIRTBXA2RMEN1KMT2AALOX15
SCHEMBL7949002 0.71 SMN1; SMN2 (0.56) PTGIRTBXA2RMEN1MAPTKMT2A
Catechol SCHEMBL9787047 0.70 ESR1 (0.57) ESR1ESR2MEN1MAPTKMT2A
SCHEMBL7960638 0.69 TBXA2R (0.30) PTGIRTBXA2R
SCHEMBL7376345 0.69 TDP1 (0.55) ESR1ESR2MEN1MAPTKMT2A
SCHEMBL7956750 0.68 PTGIR (0.61) PTGIRTBXA2RSMN1; SMN2KDM4EHPGD
SCHEMBL16026175 0.67 KDM4E (0.48) ESR1ESR2MAPTGAASMN1; SMN2
SCHEMBL7958773 0.67 PTGIR (0.59) PTGIRTBXA2RKDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1092639-C Benzene-fused heterocyclic derivative and use thereof TORAY INDUSTRIES (JP) 2002-10-16 CN disclosed
US-6323235-B1 CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS AND ENZYME INHIBITORS OHTAKE ATSUSHI (JP) 2001-11-27 US disclosed
US-6043264-A A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA TORAY INDUSTRIES, INC. (JP) 2000-03-28 US disclosed
CN-1148381-A Benzene-fused heterocyclic derivative and use thereof TORAY INDUSTRIES (JP) 1997-04-23 CN disclosed
EP-0751126-A1 BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME TORAY INDUSTRIES, INC. (JP) 1997-01-02 EP disclosed