Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 20/20 | 0.83 |
| ▸ | GABRB3 | P28472 | 20/20 | 0.83 |
| ▸ | GABRA3 | P34903 | 20/20 | 0.83 |
| ▸ | GABRA1 | P14867 | 11/20 | 0.83 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.83 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL220805 | 0.91 | GABRG2 (1.00) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2655130 | 0.90 | GABRG2 (0.82) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7960043 | 0.90 | GABRG2 (0.84) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL340891 | 0.89 | GABRG2 (1.00) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7973855 | 0.88 | GABRG2 (0.77) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7972248 | 0.87 | GABRG2 (0.82) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7959488 | 0.86 | GABRG2 (0.77) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6774402 | 0.86 | GABRG2 (0.83) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2656796 | 0.85 | GABRG2 (1.00) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341094 | 0.85 | GABRG2 (0.84) | GABRG2GABRB3GABRA3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303605-B1 | FOR THERAPY OF ANXIETY AND CONVULSIONS | MERCK SHARP & DOHME LTD. (GB) | 2001-10-16 | — | — | US | claimed |
| US-6303605-B1 | FOR THERAPY OF ANXIETY AND CONVULSIONS | MERCK SHARP & DOHME LTD. (GB) | 2001-10-16 | — | — | US | disclosed |
| EP-1056746-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999037648-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1999-07-29 | — | — | WO | disclosed |