Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960556 | 1.00 | PDE4A (0.48) | PDE4APDE4BPDE4DPDE4CKCNH2 | |
| SCHEMBL7963664 | 0.85 | KCNH2 (0.55) | PDE4APDE4BPDE4DPDE4CKCNH2 | |
| SCHEMBL7963667 | 0.85 | KCNH2 (0.55) | PDE4APDE4BPDE4DPDE4CKCNH2 | |
| SCHEMBL7963124 | 0.83 | KDM4E (0.51) | PDE4AKCNH2PKM | |
| SCHEMBL7963122 | 0.83 | KDM4E (0.51) | PDE4AKCNH2PKM | |
| SCHEMBL7960143 | 0.83 | KCNH2 (0.51) | PDE4APDE4BPDE4DPDE4CKCNH2 | |
| SCHEMBL7960140 | 0.83 | KCNH2 (0.51) | PDE4APDE4BPDE4DPDE4CKCNH2 | |
| SCHEMBL7960402 | 0.83 | PDE4A (0.43) | PDE4APDE4BPDE4DPDE4CKCNH2 | |
| SCHEMBL7955415 | 0.83 | PDE4A (0.43) | PDE4APDE4BPDE4DPDE4CKCNH2 | |
| SCHEMBL7962005 | 0.82 | CNR1 (0.48) | PDE4APDE4BPDE4DPDE4CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |