Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.55 |
| ▸ | PDE4A | P27815 | 12/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963664 | 1.00 | KCNH2 (0.55) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7960140 | 0.96 | KCNH2 (0.51) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7960143 | 0.96 | KCNH2 (0.51) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7963124 | 0.85 | KDM4E (0.51) | KCNH2PDE4A | |
| SCHEMBL7963122 | 0.85 | KDM4E (0.51) | KCNH2PDE4A | |
| SCHEMBL7960552 | 0.85 | PDE4A (0.48) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7960556 | 0.85 | PDE4A (0.48) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7960294 | 0.84 | CNR1 (0.48) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7966298 | 0.84 | CNR1 (0.48) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7962005 | 0.84 | CNR1 (0.48) | KCNH2PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |