SCHEMBL7960874

SCHEMBL7960874

CONC(=O)c1cc(-c2nn(C)c(C(F)(F)F)c2Cl)c(F)cc1Cl

nearest known ligand 0.38

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 16/20 0.38
POLB P06746 1/20 0.37
APEX1 P27695 1/20 0.37
NPC1 O15118 1/20 0.36
MAPT P10636 1/20 0.36
RAB9A P51151 1/20 0.36
GAA P10253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7960684 0.84 NTRK1 (0.35) NTRK1POLBAPEX1MAPT
SCHEMBL4067277 0.84 NTRK1 (0.37) NTRK1MAPT
SCHEMBL7970857 0.83 NTRK1 (0.37) NTRK1
SCHEMBL7970514 0.83 GAA (0.34) NTRK1GAA
SCHEMBL7960698 0.82 NTRK1 (0.36) NTRK1
SCHEMBL7591494 0.81 HTR2A (0.30)
SCHEMBL7973890 0.81 HTR2A (0.30)
SCHEMBL27320851 0.80 MAPT (0.34) NTRK1MAPTGAA
SCHEMBL7693582 0.80 POLB (0.37) POLBAPEX1NPC1MAPTRAB9A
SCHEMBL27561461 0.78 ALPL (0.36) NTRK1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6197973-B1 HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 2001-03-06 US disclosed