Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7946988 | 0.93 | KDM4E (0.43) | MCL1ALOX5MEN1KMT2AKDM4E | |
| SCHEMBL7958074 | 0.84 | MCL1 (0.66) | MCL1PDE3BPDE3AALOX5MAPK1 | |
| SCHEMBL7955774 | 0.84 | MAPK1 (0.43) | PDE3BPDE3AALOX5MAPK1MEN1 | |
| SCHEMBL7954130 | 0.81 | ALDH1A1 (0.45) | PDE3BPDE3AMAPK1MEN1KMT2A | |
| SCHEMBL7946984 | 0.80 | PDE3B (0.45) | MCL1PDE3BPDE3AALOX5MAPK1 | |
| SCHEMBL2347720 | 0.79 | MCL1 (0.54) | MCL1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7954132 | 0.78 | MAPK1 (0.41) | MAPK1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7958065 | 0.76 | ALDH1A1 (0.44) | PDE3BPDE3AMAPK1MEN1KMT2A | |
| SCHEMBL7954146 | 0.76 | KDM4E (0.41) | MAPK1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL30417424 | 0.76 | KDM4E (0.41) | MCL1ALOX5MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271251-B1 | CARDIOVASCULAR DISORDERS | SUMITOMO PHARMACEUTICALS COMPANY LIMITED (JP) | 2001-08-07 | — | — | US | disclosed |
| US-5977100-A | Substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| US-5834454-A | TREATMENT OF ANGINA, ISCHEMIA, ARRHYTHMIA | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1998-11-10 | — | — | US | disclosed |
| EP-0787728-A1 | Substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-08-06 | — | — | EP | disclosed |