Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 7/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | CASR | P41180 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960959 | 1.00 | ADRB3 (0.56) | ADRB3ADRB2ADRB1MEN1CYP1A2 | |
| SCHEMBL11585329 | 0.88 | ADRB3 (0.48) | ADRB3ADRB2ADRB1MEN1CYP1A2 | |
| SCHEMBL8180863 | 0.86 | DRD2 (0.51) | ADRB3ADRB2ADRB1MEN1CYP1A2 | |
| SCHEMBL8180860 | 0.86 | DRD2 (0.51) | ADRB3ADRB2ADRB1MEN1CYP1A2 | |
| SCHEMBL10714025 | 0.81 | ADRB3 (0.42) | ADRB3ADRB2ADRB1MEN1CYP1A2 | |
| SCHEMBL11231537 | 0.80 | DRD2 (0.66) | ADRB3ADRB2ADRB1MEN1CYP1A2 | |
| SCHEMBL7962966 | 0.78 | POLB (0.53) | MEN1CYP1A2KMT2ADRD2CYP2D6 | |
| SCHEMBL13959117 | 0.78 | ADRB3 (0.70) | ADRB3ADRB2ADRB1MEN1CYP1A2 | |
| SCHEMBL4816774 | 0.78 | ADRB3 (0.66) | ADRB3ADRB2ADRB1MEN1CYP1A2 | |
| SCHEMBL4816760 | 0.78 | ADRB3 (0.66) | ADRB3ADRB2ADRB1MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265581-B1 | REACTING SPECIFIED EPOXIDE AND AMINE, REACTING PRODUCT WITH ACID TO FORM ACID ADDITION SALT | ELI LILLY AND COMPANY | 2001-07-24 | — | — | US | disclosed |
| US-6093735-A | TREATMENT OF TYPE II DIABETES AND OBESITY | ELI LILLY AND COMPANY (US) | 2000-07-25 | — | — | US | disclosed |
| US-6075040-A | OBESITY AND DIABETES | ELI LILLY AND COMPANY (US) | 2000-06-13 | — | — | US | disclosed |
| US-6060492-A | SIDE EFFECT REDUCTION | ELI LILLY AND COMPANY (US) | 2000-05-09 | — | — | US | disclosed |
| US-5977154-A | OBESITY, DIABETES | ELI LILLY AND COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0764640-A1 | Selective beta3 adrenergic agonists | ELI LILLY AND COMPANY (US) | 1997-03-26 | — | — | EP | disclosed |
| US-4310527-A | DISORDERS OF CAROIAC RHYTHM AND CORONARY HEART DISEASES AND HYDPERTENSION | CIBA-GEIGY CORPORATION (US) | 1982-01-12 | — | — | US | disclosed |
| US-4140789-A | ADRENERGIC BLOCKING AGENTS, CARDIOTONIC, ANTIARRHYTHMIA, HYPOTENSIVE | CIBA-GEIGY CORPORATION (US) | 1979-02-20 | — | — | US | disclosed |