Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA7 | P43166 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6561033 | 0.81 | LMNA (0.39) | TSHRHPGDSMN1; SMN2NPSR1CA12 | |
| SCHEMBL14108876 | 0.72 | TSHR (0.36) | TSHRHPGDSMN1; SMN2NPSR1CA12 | |
| SCHEMBL10447298 | 0.67 | TSHR (0.48) | TSHRHPGDSMN1; SMN2CA12CA1 | |
| SCHEMBL14195937 | 0.67 | CYP1A2 (0.48) | TSHRCYP1A2LMNACYP2C9 | |
| SCHEMBL1971079 | 0.67 | CYP2C9 (0.42) | TSHRCYP1A2KDM4EALOX15LMNA | |
| SCHEMBL7002092 | 0.66 | TSHR (0.39) | TSHRBAZ2BBAZ2AHPGDCA12 | |
| Hydrochloric Acid SCHEMBL10419893 | 0.66 | CYP2C9 (0.41) | KMT2ACYP1A2KDM4EALOX15LMNA | |
| SCHEMBL4263380 | 0.64 | MEN1 (0.39) | TSHRHPGDSMN1; SMN2CA12CA1 | |
| SCHEMBL11438318 | 0.64 | TSHR (0.38) | TSHRHPGDSMN1; SMN2NPSR1CA12 | |
| SCHEMBL19204714 | 0.63 | CYP1A2 (0.38) | TSHRHPGDCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |