Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 19/20 | 1.00 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.74 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.62 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.62 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.62 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.62 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.62 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.62 |
| ▸ | PLA2G2F | Q9BZM2 | 1/20 | 0.62 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.62 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.62 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953315 | 0.92 | PLA2G2A (1.00) | PLA2G2APLA2G1BPLA2G10PLA2G6PLA2G5 | |
| SCHEMBL7965788 | 0.91 | PLA2G2A (0.83) | PLA2G2APLA2G1BPLA2G10PLA2G6PLA2G5 | |
| SCHEMBL7966068 | 0.91 | PLA2G2A (0.83) | PLA2G2APLA2G1B | |
| SCHEMBL13484790 | 0.89 | PLA2G2A (0.85) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL7965344 | 0.89 | PLA2G2A (0.83) | PLA2G2APLA2G1B | |
| SCHEMBL7963789 | 0.88 | PLA2G2A (0.83) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL7963794 | 0.88 | PLA2G2A (0.83) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL8924654 | 0.87 | PLA2G2A (0.77) | PLA2G2APLA2G1B | |
| SCHEMBL818585 | 0.85 | PLA2G2A (1.00) | PLA2G2APLA2G1BPLA2G10PLA2G6PLA2G5 | |
| SCHEMBL7966130 | 0.85 | PLA2G2A (0.74) | PLA2G2APLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620215-B1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | LILLY CO ELI (US) | 1999-08-18 | — | — | EP | claimed |
| EP-0620215-A1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | claimed |
| US-6252084-B1 | THERAPY FOR SEPSIS SHOCK | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0620215-B1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | LILLY CO ELI (US) | 1999-08-18 | — | — | EP | disclosed |
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0620215-A1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |